| Formula |
CAS |
| C7HNOS |
2634-33-5 |
Background1,2-Benzisothiazolin-3-one is a member of
the chemically related isothiazolinone group of preservatives. A Danish study
(Nielsen) found 1,2-Benzisothiazolin-3-one registered in 156 products. The most
frequently registered product categories were cleaning agents, polishes, and
paints. The concentration was less than 0.01% in 46% of products and greater
than 0.1% in 24%. The concentration was lowest in shampoos, skin care agents,
cleaning agents, printing inks, and polishes. Sensitized patients have reacted
to 0.0099% concentration in aqueous and alcohol. The isothiazolinone preservatives
include: 2-n-Octyl-4-isothiazolin-3-one, 1,2-Benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one
5-Chloro-2-methyl-4-isothiazolin-3-one
Synonyms1,2-Benzisothiazolin-3-one
BIT(1,2-Benzisothiazolin-3-one)
BT-B105
Proxel
Proxel XL
Proxel
HL (1,2-Benzisothiazolin-3-one, 30% in a mixture of morpholine di- and triethanolamine)
Proxel CRL (1,2-Benzisothiazolin-3-one + ethylenediamine)
Uses
Acrylic resin dispersions
Adhesive paper
Anti-adhesive agents
Binders
Cleaning agents
Construction materials
Curing agents
Fabric softeners
Glues
Paint (dispersion paints, non-washable distempers)
Pesticides
Photo chemicals
Pigments, pigment doughs and pastes
Plasticizers
Polishes
Preservative in cooling fluids
Proxel CRL (1,2-Benzisothiazolin-3-one + ethylenediamine)
PVC gloves (vinyl gloves)
Shampoos Shoes (heel and toe counters)
Spinning
baths (textile industry)
Surfactants
Textiles
Water-miscible cutting
oils
Wax emulsions
Cross-Reactions
Unusual Reactions
Back to list of contact allergens
Referenties
| 1. |
Alomar A. Contact dermatitis from benzisothiazolone
in cutting oils. Contact Dermatitis 1981;7(3):155-156. |
| 2. |
Alomar A, Conde-Salazar L, Romaguera C. Occupational
dermatoses from cutting oils. Contact Dermatitis 1985;12(3):129-138. |
| 3. |
Botham PA. et al. Assessment of the relative
skin sensitizing potency of 3 biocides using the murine local lymph
node assay. Contact Dermatitis 1991;25(3):172-177. |
| 4. |
Damstra RJ, van Vloten WA, van Ginkel CJ.
Allergic contact dermatitis from the preservative 1,2-benzisothiazolin-3-one
(1,2-BIT; Proxel): a case report, its prevalence in those occupationally
at risk and in the general dermatological population, and its relationship
to allergy to its analogue Kathon CG. Contact Dermatitis 1992;27(2):105-109.
|
| 5. |
Dias M, Lamarao P, Vale T. Occupational contact
allergy to 1,2-benzisothiazolin-3-one in the manufacture of air
fresheners. Contact Dermatitis 1992;27(3):205-207. |
| 6. |
Dillarstone A. 1,2-benzisothiazolin-3-one.
Contact Dermatitis 1993;28(1):53. |
| 7. |
Freeman S. Allergic contact dermatitis due
to 1,2-benzisothiazolin-3-one in gum arabic. Contact Dermatitis
1984;11(3):146-149. |
| 8. |
Nielsen H. Occupational exposure to isothiazolinones.
A study based on a product register. Contact Dermatitis 1994;31(1):18-21.
|
| 9. |
Pedersen NB. Occupational allergy from 1,2-benzisothiazolin-3-one
and other preservatives in plastic emulsions. Contact Dermatitis
1976;2(6):340-342. |
| 10. |
Roberts DL. Messenger AG, Summerly R. Occupational
dermatitis due to 1,2-benzisothiazolin-3-one in the pottery industry.
Contact Dermatitis 1981;7(3):145-147. |
| 11. |
Sanz-Gallen P. et al. Allergic contact dermatitis
due to 1,2-benzisothiazolin-3-one in paint manufacture. Contact
Dermatitis 1992;27(4):271-272. |
Auteur(s):dr. Jan R. Mekkes. Dermatoloog, Amsterdam
UMC.
ICD10: L23.9