| Formula |
CAS |
| C3H6BrNO4 |
52-51-7 |
BackgroundBronopol is a broad-spectrum preservative and antiseptic used in cosmetics, topical medicaments, and industry. Cosmetic preparations contain bronopol in concentrations of 0.01% to 0.02%. When the concentration is raised to 1% or greater, it may be a significant irritant.
Bronopol is a formaldehyde-releasing preservative and concomitant sensitization to bronopol and formaldehyde occurs in about a third of patch test clinic patients.
Synonyms1,3-Propanediol-2-Bromo-2-Nitro
2-Bromo-2-nitro-1,3-propanediol
2-Bromo-2-Nitropropane-1,3-Diol
b-Bromo-b-nitrotrimethyleneglycol
Bronopol
Bronosol
Lexgard bronopol
Onyxide 500
UsesCooling fluids
Cosmetics
Creams and lotions
Detergents
Hair dressing
Humidifers
Mascaras
Milk sampling
Paints
Shampoos
Textiles
Topical medications
Cross-ReactionsFormaldehyde
Unusual ReactionsContact urticaria
Back to list of contact allergens
Referenties
| 1. |
Camarasa JG. Contact dermatitis due to
Bronopol. Contact Dermatitis 1986;14(3):191-192. |
| 2. |
Ford GP, Beck MH. Reactions to Quaternium
15, Bronopol and Germall 115 in a standard series. Contact
Dermatitis 1986;14(5):271-274. |
| 3. |
Frosch PJ, White IR, Rycroft RJ, Lahti A,
Burrows D, Camarasa JG, Ducombs G, Wilkinson JD. Contact allergy
to Bronopol. Contact Dermatitis 1990;22(1):24-26. |
| 4. |
Perrenoud D, Bircher A, Hunziker T, Suter
H, Bruckner-Tuderman L, Stäger J, Thürlimann W, Schmid P, Suard
A, Hunziker N. Frequency of sensitization to 13 common
preservatives in Switzerland. Swiss Contact Dermatitis Research
Group. Contact Dermatitis 1994;30(5):276-279. |
Auteur(s):dr. Jan R. Mekkes. Dermatoloog, Amsterdam
UMC.
ICD10: L23.9