Cinnamic aldehyde

codes geen / geen

 

 

Formula

CAS

C9H8O

104-55-2

 
CAS: Chemical Abstract Service Registry Number
 

Background

Cinnamic aldehyde is a naturally occuring fragrance with the strong odor of cinnamon. It is found in cinnamon leaves, cinnamon bark, and the essential oils of hyacinth, myrrh, Bulgarian rose, patchouli, and other plants.
Cinnamic aldehyde is used as a fragrance in cosmetics and over-the-counter drugs as well as a flavoring agent in beverages, chewing gum, mouthwashes, and toothpaste.
Oral symptoms from toothpaste containing cinnamic aldehyde include sore mouth, dermatitis of the lips and perioral skin, swelling of the tongue, and mouth ulceration.
The International Fragrance Association recommends that cinnamic aldehyde be used with an equal proportion by weight of eugenol or d-limonene to prevent sensitization. This process is known as quenching.

 

Synonyms

2-Propenal-3-phenyl
3-Phenyl-2-propenal
Cinnamal (CTFA adopted name)
Cinnamaldehyde
Cinnamic aldehyde
Phenylacrolein

 

Uses

Balsam of Tolu and Balsam of Peru
Cinnamon, Ceylon, and Cassia oil
Foods (cola, chocolate, ice cream, chewing gums)
Fragranced household products such as deodorizers, detergents, and soaps
Perfumes
Plants (hyacinth, etc.)
Spices
Toothpaste

 

Cross-Reactions

Cinnamic acid
Cinnamic alcohol
Cinnamon oil

 

Unusual Reactions

Depigmentation
Non immunologic Contact urticaria
Photoallergy

 

References

1.

Calnan, C.D., Cinnamon dermatitis from an ointment. Contact Dermatitis, 1976. 2(3): p. 167-70.

2.

Drake, T.E. and H.I. Maibach, Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Archives of Dermatology, 1976. 112(2): p. 202-3.

3.

Fisher, A.A. and A. Dooms-Goossens, The effect of perfume "ageing" on the allergenicity of individual perfume ingredients. Contact Dermatitis, 1976. 2(3): p. 155-9.

4.

Kirton, V., Contact urticaria and cinnamic aldehyde. Contact Dermatitis, 1978. 4(6): p. 374-5.

5.

Romaguera, C. and F. Grimalt, Sensitization to cinnamic aldehyde in toothpaste. Contact Dermatitis, 1978. 4(6): p. 377-8.

6.

Mathias, C.G., R.R. Chappler, and H.I. Maibach, Contact urticaria from cinnamic aldehyde. Archives of Dermatology, 1980. 116(1): p. 74-6.

7.

Fergurson, J. and S. Sharma, Cinnamic aldehyde test concentrations [letter]. Contact Dermatitis, 1984. 10(3): p. 191-2.

8.

Guin, J.D., et al., The effect of quenching agents on contact urticaria caused by cinnamic aldehyde. Journal of the American Academy of Dermatology, 1984. 10(1): p. 45-51.

9.

Malten, K.E., et al., Reactions in selected patients to 22 fragrance materials. Contact Dermatitis, 1984. 11(1): p. 1-10.

10.

Maibach, H.I., Cheilitis: occult allergy to cinnamic aldehyde. Contact Dermatitis, 1986. 15(2): p. 106-7.

11.

Nethercott, J.R., et al., Contact dermatitis due to cinnamic aldehyde induced in a deodorant manufacturing process. Contact Dermatitis, 1983. 9(3): p. 241-2.

12.

Storrs, F.J., et al., Prevalence and relevance of allergic reactions in patients patch tested in North America--1984 to 1985. Journal of the American Academy of Dermatology, 1989. 20(6): p. 1038-45.

13.

Weibel, H. and J. Hansen, Penetration of the fragrance compounds, cinnamaldehyde and cinnamyl alcohol, through human skin in vitro. Contact Dermatitis, 1989. 20(3): p. 167-72.

14.

Speight, E.L. and C.M. Lawrence, Cinnamic aldehyde 2% pet. is irritant on patch testing. Contact Dermatitis, 1990. 23(5): p. 379-80.

15.

Meding, B., Skin symptoms among workers in a spice factory. Contact Dermatitis, 1993. 29(4): p. 202-5.

16.

Helton, J. and F. Storrs, The burning mouth syndrome: lack of a role for contact urticaria and contact dermatitis. Journal of the American Academy of Dermatology, 1994. 31(2 Pt 1): p. 201-5.

17.

Seite-Bellezza, D., F. el Sayed, and J. Bazex, Contact urticaria from cinnamic aldehyde and benzaldehyde in a confectioner. Contact Dermatitis, 1994. 31(4): p. 272-3.

18.

Johansen, J.D. and T. Menne, The fragrance mix and its constituents: a 14-year material. Contact Dermatitis, 1995. 32(1): p. 18-23.

19.

Manzur, F., F. el Sayed, and J. Bazex, Contact allergy to cinnamic aldehyde and cinnamic alcohol in Oleophytal. Contact Dermatitis, 1995. 32(1): p. 55.

 

 

 

 

 

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