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Formula |
CAS |
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C10H12O2 |
97-54-1 |
CAS: Chemical Abstract Service Registry Number
Background
Isoeugenol is a fragrance and spice with the odor of cloves. It is found in the oils of clove, ylang-ylang, tuberose, and jonquil. It is manufactured by the isomerization of eugenol. The International Fragrance Research Association recommends that isoeugenol be used at no more than a 1% concentration in fragrance compounds. It is an approved flavoring agent for foods.
Synonyms
2-Methoxy-4-(1-propenyl) phenol
2-Methoxy-4-propenylphenol
4-Hydroxy-3-methoxy-1-propenylbenzene
4-Propenyl-2-methoxyphenol
4 -Propenylguaiacol
Benzylisoeugenol
Isoeugenol acetate
Isoeugenol methyl ether
Uses
Cosmetics (clove and carnation scent)
Dental materials
Food flavor
Dental materials
Over-the-counter medicines
Perfumes
Production of vanillin flavor
Cross-Reactions
Eugenol
Unusual Reactions
References
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1. |
Maurer, T., et al., Predictive evaluation in animals of the contact allergenic potential of medically important substances. II. Comparison of different methods of cutaneous sensitization with "weak" allergens. Contact Dermatitis, 1979. 5(1): p. 1-10. |
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2. |
de Groot, A.C., et al., Patch tests with fragrance materials and preservatives. Contact Dermatitis, 1985. 12(2): p. 87-92. |
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3. |
Roberts, D.W., B.F. Goodwin, and D. Basketter, Methyl groups as antigenic determinants in skin sensitisation. Contact Dermatitis, 1988. 18(4): p. 219-25. |
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4. |
Roesyanto-Mahadi, I.D., et al., Sensitization to fragrance materials in Indonesian cosmetics. Contact Dermatitis, 1990. 22(4): p. 212-7. |
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5. |
Barratt, M.D. and D.A. Basketter, Possible origin of the skin sensitization potential of isoeugenol and related compounds. (I). Preliminary studies of potential reaction mechanisms. Contact Dermatitis, 1992. 27(2): p. 98-104. |
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6. |
de Groot, A.C., et al., Frequency of false-negative reactions to the fragrance mix. Contact Dermatitis, 1993. 28(3): p. 139-40. |
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7. |
Garrigue, J.L., et al., Optimization of the mouse ear swelling test for in vivo and in vitro studies of weak contact sensitizers. Contact Dermatitis, 1994. 30(4): p. 231-7. |
13-06-2011
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