|
Formula |
CAS |
|
|
|
CAS: Chemical Abstract Service Registry Number
Background
Polyethylene glycols (PEGs) are used extensively as solvent vehicles in
cosmetics, industrial products and technical industries. The molecular
weights vary from 200 to 7500. At room temperature, the low molecular weigth
(200 - 700) are liquids, whereas the consistency of higher molecular PEGs
(1000 - 7500) varies from soft to hard. PEGs are hydrophilic and easily
bind many products becaused of theric special helical configuration. PEGs
are therfore used as a vehicle for many drugs. PEGs (especially PEG 400)
facilitate the skin penetration of many substances and are therfore often
used in topical preparations. PEGs are not subject ot bacterial deterioration.
Peroxidases may be formed during storage, especially at higher temperatures
or in daylight, so storage conditions should preferably be a cool environment
protected from direct sunlight.
Cross reactions occurr between the low molecular weight but not the
higher molecular weight PEGs and the higher molecular weight PEGs are consisdered
to be rare sensitizers.
Synonyms
Polyethylene glycol 400
Uses
Carbowax
Contraceptives
Topical medications
Shampoos
Detergents
Insect repellents
Cosmetics
Toothpaste
Furacin
Hair dressings
Plastibase
Suppositores
Cross-Reactions
Unusual Reactions
References
|
1. |
Fisher, A.A., Contact urticaria due to polyethylene glycol. Cutis, 1977. 19(4): p. 409-12. |
|
2. |
Fisher, A.A., Immediate and delayed allergic contact reactions to polyethylene glycol. Contact Dermatitis, 1978. 4(3): p. 135-8. |
|
3. |
Daly, B.M., Bactroban allergy due to polyethylene glycol. Contact Dermatitis, 1987. 17(1): p. 48-9. |
|
4. |
Bajaj, A.K., et al., Contact sensitivity to polyethylene glycols. Contact Dermatitis, 1990. 22(5): p. 291-2. |
|
5. |
Stenveld, H.J., P.N. Langendijk, and D.P. Bruynzeel, Contact sensitivity to polyethylene glycols. Contact Dermatitis, 1994. 30(3): p. 184-5. |
08-01-2012
(JRM) - www.huidziekten.nl