Dal Pozzo et al. hebben een algoritme bedacht voor dermatoscopie bij melanoom,
waarbij ze alleen scoren op 7 kenmerken:
1. Irregular pigment network
(2 punten)
2. Regression-erythema (2 punten)
3. Unhomogeneity (2 punten)
4. Sharp margin (2 punten)
5. Pseudopods (1 punt)
6. Radial streaming
(1 punt)
7. Gray-blue veil (1 punt)
Bij 3 punten is er verdenking
op een melanoom. Met deze 7 kenmerken (
dermatoscopy 7-item-checklist)
bereikten ze een sensitiviteit van 94.6%, en een specificiteit van 85.5%.

Figure 1. Irregular pigment network shows broad mesh and varying features in
the same lesions, melanoma, level II, thickness 0.23 mm.

Figure 2. Regression-erythema is a white pinkish depigmented area possibly with
a few angiectases, melanoma, level II, thickness 0.59 mm.

Figure 3. Unhomogeneity is an asymmetrical or irregular distribution in the
lesion of at least two dermoscopic features not necessarily predictive of malignancy.
In this lesion globules and a pigment network show an asymmetrical distribution,
melanoma, level II, thickness 0.62 mm.

Figure 4. Sharp margin: abrupt cessation of the dermoscopic features at the
periphery of the lesion not < 1/4 of the margin, melanoma, level II, thickness
0.42 mm.

Figure 5. Pseudopods: this lesion presents irregularly distributed pseudopods,
melanoma, level II, thickness 0.54 mm.

Figure 6. Radial streaming are thin, closely spaced, parallel pigmented streaming
irradiating from the rim of the lesion, melanoma, level II, thickness 0.20 mm.

Figure 7. Gray-blue veil: a blue or gray-faded blue area with ill-defined margins,
asymmetrically located inside the lesion, melanoma, level II, thickness 0.98
mm.
Referenties
1. |
Dal Pozzo V, Benelli C, Roscetti E. The seven
features for melanoma: a new dermoscopic algorithm for the diagnosis
of malignant melanoma. European Journal of Dermatology 1999;9:303-308. |
Auteur(s):dr. Jan R. Mekkes. Dermatoloog, Amsterdam
UMC.