1,2-Benzisothiazolin-3-one

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        1,2-benzisothiazolin-3-one conserveringsmiddel (klik op foto voor vergroting)

 

Formula

CAS

C7HNOS

2634-33-5

 
CAS: Chemical Abstract Service Registry Number
 

Background

1,2-Benzisothiazolin-3-one is a member of the chemically related isothiazolinone group of preservatives. A Danish study (Nielsen) found 1,2-Benzisothiazolin-3-one registered in 156 products. The most frequently registered product categories were cleaning agents, polishes, and paints. The concentration was less than 0.01% in 46% of products and greater than 0.1% in 24%. The concentration was lowest in shampoos, skin care agents, cleaning agents, printing inks, and polishes. Sensitized patients have reacted to 0.0099% concentration in aqueous and alcohol.

 
The isothiazolinone preservatives include:

2-n-Octyl-4-isothiazolin-3-one,

1,2-Benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one
5-Chloro-2-methyl-4-isothiazolin-3-one

 

Synonyms

1,2-Benzisothiazolin-3-one

BIT(1,2-Benzisothiazolin-3-one)

BT-B105
Proxel
Proxel XL
Proxel HL (1,2-Benzisothiazolin-3-one, 30% in a mixture of morpholine di- and triethanolamine)
Proxel CRL (1,2-Benzisothiazolin-3-one + ethylenediamine)

 

Uses

Acrylic resin dispersions

Adhesive paper
Anti-adhesive agents
Binders
Cleaning agents
Construction materials
Curing agents
Fabric softeners

Glues
Paint (dispersion paints, non-washable distempers)
Pesticides

Photo chemicals
Pigments, pigment doughs and pastes
Plasticizers
Polishes
Preservative in cooling fluids
Proxel CRL (1,2-Benzisothiazolin-3-one + ethylenediamine)

PVC gloves (vinyl gloves)
Shampoos
Shoes (heel and toe counters)

Spinning baths (textile industry)
Surfactants
Textiles

Water-miscible cutting oils

Wax emulsions

 

 

Cross-Reactions

 

 

Unusual Reactions

 

 

Print een folder in het Nederlands over dit productProductkenmerken (Summary in Dutch)

1,2-Benzisothiazolin-3-one is een conserveringsmiddel behorend tot de isothiazolinone groep. Deze bestaat uit:

 - 2-n-Octyl-4-isothiazolin-3-one

 - 1,2-Benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one
 - 5-Chloro-2-methyl-4-isothiazolin-3-one

Deze conserveringsmiddelen worden toegevoegd aan talloze industriŽle producten. 1,2-Benzisothiazolin-3-one wordt het meest gevonden in reinigingsmiddelen, polijstmiddelen en in verven (meestal op waterbasis). Maar het komt ook voor in een lage concentratie in shampoo, huidverzorgingsproducten en printerinkt.

 

Producten waar het in voorkomt: 

Acryl harsen, plakband, reinigingsmiddelen, polijstmiddelen, was, weekmakers, lijmen, verf (spuitverf, latexverf), fotochemicaliŽn, pesticiden, pigmenten, snij- en draai-olie, printer inkt, shampoo, verfbaden in de textielindustrie, surfactans, schoenzolen, PVC handschoenen en vele andere industriŽle producten.

 

Allergeen testsubstantie: 1,2-Benzisothiazolin-3one, Na-Salt 0.1% Van der Bend E2471 (reeks: cutting oils I  / snij olien)

 

 

References

 1.

Alomar A. Contact dermatitis from benzisothiazolone in cutting oils. Contact Dermatitis 1981;7(3):155-156.

 2.

Alomar A, Conde-Salazar L, Romaguera C. Occupational dermatoses from cutting oils. Contact Dermatitis 1985;12(3):129-138.

 3.

Botham PA. et al. Assessment of the relative skin sensitizing potency of 3 biocides using the murine local lymph node assay. Contact Dermatitis 1991;25(3):172-177.

 4.

Damstra RJ, van Vloten WA, van Ginkel CJ. Allergic contact dermatitis from the preservative 1,2-benzisothiazolin-3-one (1,2-BIT; Proxel): a case report, its prevalence in those occupationally at risk and in the general dermatological population, and its relationship to allergy to its analogue Kathon CG. Contact Dermatitis 1992;27(2):105-109.

 5.

Dias M, Lamarao P, Vale T. Occupational contact allergy to 1,2-benzisothiazolin-3-one in the manufacture of air fresheners. Contact Dermatitis 1992;27(3):205-207.

 6.

Dillarstone A. 1,2-benzisothiazolin-3-one. Contact Dermatitis 1993;28(1):53.

 7.

Freeman S. Allergic contact dermatitis due to 1,2-benzisothiazolin-3-one in gum arabic. Contact Dermatitis 1984;11(3):146-149.

 8.

Nielsen H. Occupational exposure to isothiazolinones. A study based on a product register. Contact Dermatitis 1994;31(1):18-21.

 9.

Pedersen NB. Occupational allergy from 1,2-benzisothiazolin-3-one and other preservatives in plastic emulsions. Contact Dermatitis 1976;2(6):340-342.

10.

Roberts DL. Messenger AG, Summerly R. Occupational dermatitis due to 1,2-benzisothiazolin-3-one in the pottery industry. Contact Dermatitis 1981;7(3):145-147.

11.

Sanz-Gallen P. et al. Allergic contact dermatitis due to 1,2-benzisothiazolin-3-one in paint manufacture. Contact Dermatitis 1992;27(4):271-272.

 

 

 

 

 

Omhoog21-06-2012 (JRM) -  www.huidziekten.nl