|
Formula |
CAS |
|
C3H6BrNO4 |
52-51-7 |
CAS: Chemical Abstract Service Registry Number
Background
Bronopol is a broad-spectrum preservative and antiseptic used in cosmetics,
topical medicaments, and industry. Cosmetic preparations contain bronopol
in concentrations of 0.01% to 0.02%. When the concentration is raised to
1% or greater, it may be a significant irritant.
Bronopol is a formaldehyde-releasing preservative and concomitant sensitization
to bronopol and formaldehyde occurs in about a third of patch test clinic
patients.
Synonyms
1,3-Propanediol-2-Bromo-2-Nitro
2-Bromo-2-nitro-1,3-propanediol
2-Bromo-2-Nitropropane-1,3-Diol
b-Bromo-b-nitrotrimethyleneglycol
Bronopol
Bronosol
Lexgard bronopol
Onyxide 500
Uses
Cooling fluids
Cosmetics
Creams and lotions
Detergents
Hair dressing
Humidifers
Mascaras
Milk sampling
Paints
Shampoos
Textiles
Topical medications
Cross-Reactions
Formaldehyde
Unusual Reactions
References
|
1. |
Maibach, H.I., Dermal sensitization potential of 2-bromo-2-nitropropane-1,3-diol (Bronopol). Contact Dermatitis, 1977. 3(2): p. 99. |
|
2. |
Peters, M.S., S.M. Connolly, and A.L. Schroeter, Bronopol allergic contact dermatitis. Contact Dermatitis, 1983. 9(5): p. 397-401. |
|
3. |
Camarasa, J.G., Contact dermatitis due to Bronopol. Contact Dermatitis, 1986. 14(3): p. 191-2. |
|
4. |
Ford, G.P. and M.H. Beck, Reactions to Quaternium 15, Bronopol and Germall 115 in a standard series. Contact Dermatitis, 1986. 14(5): p. 271-4. |
|
5. |
Frosch, P.J., et al., Contact allergy to Bronopol. Contact Dermatitis, 1990. 22(1): p. 24-6. |
|
6. |
Perrenoud, D., et al., Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group. Contact Dermatitis, 1994. 30(5): p. 276-9. |
13-06-2011
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