5-Chloro-2-methyl-4-isothiazolin-3-one

codes geen / geen

 

 

Formula

CAS

C4H4ClNOS

26172-55-4

 
CAS: Chemical Abstract Service Registry Number
 

Background

5-Chloro-2-methyl-4-isothiazolin-3-one is a memberof the chemically related Isothiazolinone group of preservatives. It is generally combined with 2-methyl-4-isothiazolin-3-one when used (MCI/MI) (Kathon CG).
The isothiazolinone preservatives include: 2-n-Octyl-4-isothiazolin-3-one, 1,2-Benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, and 5-Chloro-2-methyl-4-isothiazolin-3-one. 

 

Synonyms

2-methyl-4-isothiazolin-3-one
5-Chloro-2-methyl-4-isothiazolin-3-one
Acticide
Algucid CH50
Amerstat 250
Euxyl K 100
Cl+Me-isothiazolinone
Fennosan IT 21
Grotan K
Grotan TK2
GR 856 Izolin
Kathon 886 MW
Kathon CG
Kathon DP
Kathon LX
Kathon UT
Kathon WT
Mergal K7
Metat GT
Metatin GT
Methylchloroisothiazolinone/Methylisothiazolinone
Mitco CC 32 L
Paretol
Parmetol DF 35, -DF 12, -A23, -K50, -K40, -DF 18
P3 Multan D
Piror P109
Special Mx 323

 

Uses

Adhesives/glues
Binders
Bubble baths
Cleaning agents
Cooling tower water
Cosmetics, especially shampoos
Curing agents
Detergents
Fabric softeners
Fillings
Hair and body gels
Household cleaning products
Jet fuels
Latex emulsions
Mascaras
Metalworking fluids
Milk sampling
Moist toilet paper
Oil and cooling fluids
Paints
Pesticides
Sanitation products
Pigments
Polishes
Preservatives
Printing inks
Radiography
Shampoos
Slime control in paper mills
Soaps

 

Cross-Reactions

 

 

Unusual Reactions

Airborne contact dermatitis

 

References

1.

de Groot, A.C., D.H. Liem, and J.W. Weyland, Kathon CG: cosmetic allergy and patch test sensitization. Contact Dermatitis, 1985. 12(2): p. 76-80.

2.

Bruze, M., et al., Contact allergy to the active ingredients of Kathon CG. Contact Dermatitis, 1987. 16(4): p. 183-8.

3.

Bruze, M., et al., Contact allergy to the active ingredients of Kathon CG in the guinea pig. Acta Dermato-Venereologica, 1987. 67(4): p. 315-20.

4.

de Groot, A.C. and J.W. Weyland, Kathon CG: a review. Journal of the American Academy of Dermatology, 1988. 18(2 Pt 1): p. 350-8.

5.

Bruze, M., B. Gruvberger, and E. Hradil, Occupational allergic contact dermatitis due to methylisothiazolinones in a cleansing cream. Contact Dermatitis, 1990. 22(4): p. 235-7.

6.

Foussereau, J., An epidemiological study of contact allergy to 5-chloro-3-methyl isothiazolone/3-methyl isothiazolone in Strasbourg. Contact Dermatitis, 1990. 22(2): p. 68-70.

7.

Rastogi, S.C., Kathon CG and cosmetic products [see comments]. Contact Dermatitis, 1990. 22(3): p. 155-60.

8.

Rietschel, R.L., et al., Methylchloroisothiazolinone-methylisothiazolinone reactions in patients screened for vehicle and preservative hypersensitivity. Journal of the American Academy of Dermatology, 1990. 22(5 Pt 1): p. 734-8.

9.

Farm, G. and J.E. Wahlberg, Isothiazolinones (MCI/MI): 200 ppm versus 100 ppm in the standard series. Contact Dermatitis, 1991. 25(2): p. 104-7.

10.

Menne, T., et al., Contact sensitization to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (MCI/MI). A European multicentre study. Contact Dermatitis, 1991. 24(5): p. 334-41.

11.

Menne, T., Relationship between use test and threshold patch test concentration in patients sensitive to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (MCI/MI). Contact Dermatitis, 1991. 24(5): p. 375.

12.

Hunziker, N., et al., Sensitization to the isothiazolinone biocide. Report of the Swiss Contact Dermatitis Research Group 1988-1990. Dermatology, 1992. 184(2): p. 94-7.

13.

Nielsen, H., Occupational exposure to isothiazolinones. A study based on a product register. Contact Dermatitis, 1994. 31(1): p. 18-21.

 

 

 

 

 

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