Abietic acid home ICD10: L23.9

Abietic acid

Formula CAS
C20H30O2 514-10-3

Nederlands

Background
Abietic acid (abietinic acid or sylvic acid) is an organic compound that occurs widely in trees. It is the primary component of resin acid, is the primary irritant in pine wood and resin, isolated from rosin (via isomerization) and is the most abundant of several closely related organic acids that constitute most of rosin, the solid portion of the oleoresin of coniferous trees. Its ester or salt is called an abietate. Abietic acid is extracted from tree rosin. It belongs to the abietane diterpene group of organic compounds derived from four isoprene units. It is used in lacquers, varnishes, and soaps, and for the analysis of resins and the preparation of metal resinates, plastics and paper. It is found in Pinus insularis (Khasi Pine), Pinus kesiya Royle, Pinus strobus (Eastern White Pine), and Pinus sylvestris (Scots Pine). Rosin has been used for centuries for caulking ships. It is also rubbed on the bows of musical instruments to make them less slippery. Resin acids are converted into ester gum by reaction with controlled amounts of glycerol or other polyhydric alcohols. Ester gum has drying properties and is used in paints, varnishes, and lacquers. Rosin has been used to depackage integrated circuits from their epoxy coatings.

Synonyms
[1R-(1a,4ab,4ba,10a(a)]-1,2,3,4,4a,4 b,5,6,10,10a-Decahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acid
13-Isoporpylpodocarpa-7,13-dien-15-oic acid
Abietic acid
Sylvic acid
13-Isopropylpodocarpa-7,13-dien-15-oic acid
7,13-Abietadien-18-oic acid
AI3-17273
Abietate
CCRIS 3183
EINECS 208-178-3
Kyselina abietova
NSC 25149

Uses
Adhesive tape
Brown soaps
Chewing gums
Cleansing agents
Deodorizing agent in cooling fluids
Cosmetics
Cutting fluids
Dental impression materials
Deodorizing agent
Glue
Inks
Insulating tapes
Ostomy appliances
Papers
Polishes
Sealants
Soldering fluxes
Ulcer bandages
Varnishes
Violinists' rosin

Cross-Reactions
Colophony
Dihydroabietyl alcohol

Unusual Reactions
Contact urticaria

Back to list of contact allergens

Referenties
1. Wahlberg JE. Abietic acid and colophony. Contact Dermatitis 1978;4(1):55.
2. Karlberg AT, Boman A, Wahlberg JE. Allergenic potential of abietic acid, colophony and pine resin-HA. Clinical and experimental studies. Contact Dermatitis 1980;6(7):481-487.
3. Karlberg AT, et al. Is abietic acid the allergenic component of colophony? Contact Dermatitis 1985;13(4):209-215.
4. Karlberg AT. Pure abietic acid is not allergenic [letter; comment]. Contact Dermatitis 1989;21(4):282-285.
5. Hausen BM et al. Contact allergy due to colophony (III). Sensitizing potency of resin acids and some related products [see comments]. Contact Dermatitis 1989;20(1):41-50.
6. Hausen BM, Krohn K, Budianto E. Contact allergy due to colophony (VII). Sensitizing studies with oxidation products of abietic and related acids. Contact Dermatitis 1990;23(5):352-358.
7. Shao LP et al. The allergenicity of glycerol esters and other esters of rosin (colophony). Contact Dermatitis 1993;28(4):229-234.
8. Gafvert E et al. Allergenicity of rosin (colophony) esters (II). Glyceryl monoabietate identified as contact allergen. Contact Dermatitis 1994;31(1):11-17.
9. Gafvert E. Allergenic components in modified and unmodified rosin. Chemical characterization and studies of allergenic activity. Acta Dermato-Venereologica. Supplementum 1994;184:1-36.
10. Fisher AA. Allergic contact dermatitis in a violinist. The role of abietic acid - a sensitizer in rosin (colophony) - as the causative agent. Cutis 1981;27(5):466, 468, 473.
11. El Sayed F, Manzur F, Bayle P, Marguery MS, Bazex J. Contact urticaria from abietic acid. Contact dermatitis 1995;32(6):361-362.


Auteur(s):
dr. Jan R. Mekkes. Dermatoloog, Amsterdam UMC.

03-08-2023 (JRM) - www.huidziekten.nl W3C-html-4.01-valid