Alantolactone home ICD10: L23.9


Formula CAS
C15H20O2 546-43-0

Alantolactone is a sesquiterpene lactone. It is a component of Helenin, a phytochemical mixture found in many plant species, including the Inula helenium (elecampane) of the family Asteraceae. Helenin is a mixture of two isomeric sesquiterpene lactones, alantolactone and isoalantolactone.

[3aR-(3aa,5b,8ab,9aa)]-3a,5,6,7,8,8 a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho-[2,3-b]furan-2(3H)-one 8b-hydroxy-4aH-eudesm-5-en-12-oic aic g-lactone
Alant camphor
Elecampane camphor
Inula camphor Eupatal

Chrysanthemum (Helenin)
Inula helenium


Unusual Reactions

Back to list of contact allergens

1. Roed-Petersen J, Hjorth N. Compositae sensitivity among patients with contact dermatitis: value of compositae oleoresins in a standard test series. Contact Dermatitis 1976;2(5):271-281.
2. Campolmi P, Sertoli A, Fabbri P, Panconesi E. Alantolactone sensitivity in chrysanthemum contact dermatitis. Contact Dermatitis 1978;4(2):93-102.
3. Stampf JL, Schlewer G, Ducombs G, Foussereau J, Benezra C. Allergic contact dermatitis due to sesquiterpene lactones. A comparative study of human and animal sensitivity to alpha-methylene-gamma-butyrolactone and derivatives. Br J Dermatol 1978;99(2):163-169.
4. Stampf JL, Benezra C, Klecak G, Geleick H, Schulz KH, Hausen B. The sensitizing capacity of helenin and of two of its main constituents, the sesquiterpene lactones alantolactone and isoalantolactone: a comparison of epicutaneous and intradermal sensitizing methods in different strains of guinea pig. Contact Dermatitis 1982;8(1):16-24.
5. Fernández de Corres L. Contact dermatitis from Frullania, Compositae and other plants. Contact Dermatitis 1984;11(2):74-79.

dr. Jan R. Mekkes. Dermatoloog, Amsterdam UMC.

06-08-2023 (JRM) - W3C-html-4.01-valid