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Formula |
CAS |
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C28H37ClO7 |
66734-13-2 |
CAS: Chemical Abstract Service Registry Number
Background
Alclomethasone-17,21-dipropionate is a mild potency topical non-fluorinated corticosteroid with low systemic effects. It has been used since 1986 for the treatment of corticosteroid responsive dermatoses. It is ranked in Group 6 based on potency and has been classified as group D by Coopman et al. According the A-D grouping, patch-test reactions occur 6-7 times more frequently within well-defined groups of structurally related chemicals than between corticosteroids of different groups.
Synonyms
Alclomethasone-17,21-dipropionate
Alclovate ®
7-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
7a-Chloro-16a-methyl-prednisolone
Uses
Topical anti-inflammatory
Cross-Reactions
Goup D Corticosteroids
Alclomethasone dipropionate
Betamethasone dipropionate
Betamethasone valerate
Clobetasone-17-butyrate
Clobetasone-17-propionate
Fluocortolone caproate
Fluocortolone pivalate
Fluprenidene acetate
Hydrocortisone-17-butyrate
Hydrocortisone-17-valerate
Unusual Reactions
References
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1. |
Dooms-Goossens, A.E., et al., Contact allergy to corticosteroids: a frequently missed diagnosis?. Journal of the American Academy of Dermatology, 1989. 21(3 Pt 1): p. 538-43. |
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2. |
Coopman, S., H. Degreef, and A. Dooms-Goossens, Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. British Journal of Dermatology, 1989. 121(1): p. 27-34. |
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3. |
Kabasawa, Y. and T. Kanzaki, Allergic contact dermatitis from alclometasone dipropionate [see comments]. Contact Dermatitis, 1990. 23(5): p. 374-5. |
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4. |
Reitamo, S., A.I. Lauerma, and L. Forstrom, Alclometasone dipropionate allergy [letter; comment]. Contact Dermatitis, 1991. 25(1): p. 78. |
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5. |
Blancas, R., A. Ancona, and A. Arévalo, Allergic contact dermatitis from alclomethasone dipropionate. American Journal of Contact Dermatitis, 1995. 6(2): p. 115-116. |
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6. |
Lepoittevin, J.P., J. Drieghe, and A. Dooms-Goossens, Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids [see comments]. Archives of Dermatology, 1995. 131(1): p. 31-7. |
23-04-2011
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