Amcinonide

codes geen / geen

 

 

Formula

CAS

C28H35FO7

51022-69-6

 
CAS: Chemical Abstract Service Registry Number
 

Background

Amcinonide is a high-potency topical and systemic corticosteroid. It has been classified as group B by Coopman et al. According the A-D grouping, patch-test reactions occur 6-7 times more frequently within well-defined groups of structurally related chemicals than between corticosteroids of different groups. 

 

Synonyms

Amcinonide
21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene=3,20-dione cyclic 16,17-acetal with cyclopentanone, 21-acetate
CL-34699
Amciderm
Cyclocort
Penticort

 

Uses

Corticosteroid
Anti-inflammatory
Pharmaceutical

 

Cross-Reactions

budesonide, triamcinolone acetonide, fluocinonide, prednicarbate, hydrocortisone-17-butyrate.

 

Unusual Reactions

   

 

Productkenmerken (Summary in Dutch)

Amcinonide is een sterk corticostero´d uit de B groep, waarvoor vaker dan gemiddeld contactallergieŰn optreden. Het is mede om die redenen in Nederland niet meer op de markt (Amicla was de merknaam). Het is nog wel als allergeen bestelbaar en is opgenomen in de plakproefreeks corticostero´den.

 

Allergeen testsubstantie: Amcinonide  0.1% Van der Bend E2481 (reeks: corticosteroids / corticostero´den)

 

 

References

1.

Boujnah-Khouadja A, et al. Allergy to 2 new corticoid molecules. Contact Dermatitis 1984;11(2):83-87.

2.

Guin JD. Contact sensitivity to topical corticosteroids. Journal of the American Academy of Dermatology 1984; 10(5 Pt 1):773-782.

3.

Hayakawa R, et al. Allergic contact dermatitis from amcinonide. Contact Dermatitis 1985;12(4):213-214.

4.

Kubo Y, Nonaka S, Yoshida H. Contact allergy to amcinonide. Contact Dermatitis 1986;15(2):109-111.

5.

Hayakawa R, et al. Contact dermatitis from amcinonide. Contact Dermatitis 1987;16(1):48-49.

6.

Sasaki E, et al. Contact dermatitis due to amcinonide. Contact Dermatitis, 1988;18(1):61-62.

7.

Coopman S, Degreef H, Dooms-Goossens A. Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. British Journal of Dermatology 1989;121(1):27-34.

8.

Rivara G, Tomb RR, Foussereau J. Allergic contact dermatitis from topical corticosteroids. Contact Dermatitis 1989;21(2):83-91.

9.

Hayakawa R, et al. Allergic contact dermatitis due to amcinonide. Contact Dermatitis 1990;23(1):49-50.

10.

Dunkel FG, Elsner P, Burg G. Contact allergies to topical corticosteroids: 10 cases of contact dermatitis. Contact Dermatitis 1991;25(2):97-103.

11.

Gamboa PM, Jauregui I, Antepara I. Contact dermatitis from budesonide in a nasal spray without cross-reactivity to amcinonide. Contact Dermatitis 1991;24(3):227-228.

12.

Hisa T, et al. Contact allergies to topical corticosteroids. Contact Dermatitis 1993;28(3):174-179.

13.

Noda H, et al. Contact sensitivity and cross-reactivity of budesonide. Contact Dermatitis 1993;28(4):212-215.

14.

Lepoittevin JP, Drieghe J, Dooms-Goossens A. Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids. Archives of Dermatology 1995;131(1):31-37.

 

 

 

 

 

Omhoog23-05-2011 (JRM) -  www.huidziekten.nl