Bacitracin

codes geen / geen

 

 

        

 

Formula

CAS

C66H103N17O16S

1405-87-4

 
CAS: Chemical Abstract Service Registry Number
 

Background

Bacitracin is an antibiotic polypeptide complex produced by Bacillus subtillis and Bacillus licheniformis and is effective against gram-positive organisms and spirochetes. Bacitracin inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Commercial bacitracin is a mixture of at least nine bacitracins. Bacitracin A is the major component of commercial bacitracins. Bacitracin appears to be a particularly common allergen in leg ulcer treatment and post-operatively.

   

Synonyms

Ayfivin
Altracin
Ayfivin
Baciguent
Baci-Jel
Baciliquin
Bacitek Ointment
Bacitracin
Bacitracin zinc
Fortracin
Parentracin
Penitracin
Topitracin
Zutracin

 

Uses

Antibacterial ointments and creams
Ear ointments or drops
Eye ointments or drops

 

Cross-Reactions

Polymyxin B sulfate
Neomycin sulfate

 

Unusual Reactions

Immunologic contact urticaria
Anaphylaxis

 

Productkenmerken (Summary in Dutch)

Bacitracine is een antibioticum dat voornamelijk werkzaam is tegen grampositieve micro-organismen (waaronder streptokokken, pneumokokken en enterokokken). Het wordt in Nederland gebruikt in lokale antibacteriŽle producten zoals oogdruppels, oogzalven, keel-zuigtabletten, wondverzorgingsproducten, Bacicoline-B oordruppels en in over the counter producten. Soms in combinatie met neomycine. Bacitracine kan een contacteczeem veroorzaken en is opgenomen in de antibiotica-reeks.

  

Allergeen testsubstantie: Bacitracin 20% Van der Bend E2151 (reeks: antibiotica)

 

 

References

 1.

Binnick AN, Clendenning WE. Bacitracin contact dermatitis [letter]. Contact Dermatitis 1978;4(3):180-181.

 2.

Fraki JE, Peltonen L, Hopsu-Havu VK. Allergy to various components of topical preparations in stasis dermatitis and leg ulcer. Contact Dermatitis 1979;5(2):97-100.

 3.

Held JL, et al. Allergic contact dermatitis from bacitracin. Journal of the American Academy of Dermatology 1987;17(4):592-594.

 4.

Katz BE, Fisher AA. Bacitracin: a unique topical antibiotic sensitizer. Journal of the American Academy of Dermatology 1987;17(6):1016-1024.

 5.

Grandinetti PJ, Fowler Jr JF. Simultaneous contact allergy to neomycin, bacitracin, and polymyxin. Journal of the American Academy of Dermatology 1990;23(4 Pt 1):646-647.

 6.

Gette MT, Marks Jr JG, Maloney ME. Frequency of postoperative allergic contact dermatitis to topical antibiotics. Archives of Dermatology 1992;128(3):365-367.

 7.

Zaki I, Shall L, Dalziel KL. Bacitracin: a significant sensitizer in leg ulcer patients? Contact Dermatitis 1994;31(2):92-94.

 8.

Farley M, et al. Anaphylaxis to topically applied bacitracin. American Journal of Contact Dermatitis 1995;6(1):28-31.

 9.

Storm DR. N Y Acad Sci 1974;235:387.

10.

Craig LC, et. al. Ciba Foundation Symposium on Amino Acids and Peptides with Antimetabolic Activity, G. E. W. Wolstenholme and C.M. O'Connor, Eds., pp. 226-246, Little & Brown, Boston (1958).

11.

Weinberg ED. Antibiotics. In Gottlieb D, Shaw PD (eds)., pp. 90-99 and 240-245, Springer Verlag, New York (1967).

12.

Storm DR, Toscano Jr WA. Antibiotics, Vol. 5, Part 1, pp. 1-17, F. E. Hahn, Ed., Springer Verlag, New York (1979).

 

 

 

 

 

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