Methylisothiazolinon (2-methyl-4-isothiazolin-3-on)  home ICD10: L23.9

Methylisothiazolinon

Formule CAS
C4H5NOS 2682-20-4

Nederlands

Background
Methylisothiazolinone (C4H5NOS) is an heterocyclic organic compound. The IUPAC-name (International Union of Pure and Applied Chemistry) is 2-methyl-1,2-thiazol-3-on; synonym: 2-methyl-4-isothiazolin-3-on. Methylisothiazolinon is a very effectief conservative, in low dose active against grampositive and gramnegative bacteria. Methylisothiazolinon is used in many cosmetic products, both stay-on- and rinse-off-products. It is used in moist toilet paper for babies and adults, and in many consumer- and industrial products. Approximately 5% (2.6-13%) of tested patients have a positive patchtest, and in 50-100% the allergic reaction was the cause of the dermatitis.

Synonyms
2-methyl-4-isothiazolin-3-on
Euxyl K220
Neolone 950
Microcare MT
Kordek MLX

Uses
Absorbing products
Adhesives
Anti corrosion agents
Air cleaners
Binders
Cleaning agents
Construction materials
Cosmetics
Curing agents
Detergents
Fabric softener
Fillers
Glues
Hand cleaners
Impregnating fluids
Laquer
Latex emulsions
Leather conditoners
Metalworking fluids
Moist toilet paper
Oil and cooling fluids
Paints
Pesticides
Printing inks
Pigments
Polishes
Rinsing fluids
Sanitation products
Soaps
Solvents
Topical medication
Ultrasound gel
Viscosity modulators

Cross-Reactions
Methylisothiazolinone/methylchloroisothiazolinone (Kathon CG)

Unusual Reactions
Airborne contactdermatitis


References
1. de Groot AC. Methylisothiazolinon. Oorzaak van een ‘epidemie’ van contactallergie en allergisch contactzeem. Ned Tijdschr Dermatol Venereol 2017;27:77-80.
2. de Groot AC, Herxheimer A. Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis. The Lancet 1989;1:314-316.
3. de Groot AC. Methylisothiazolinone/methylchloroisothiazolinone (Kathon CG) allergy: an updated review. Amer J Contact Dermatitis 1990;1:151-156.
4. Isaksson M, Hauksson I, Hindsén M, Pontén A, Svedman C, Bruze M. Methylisothiazolinone contact allergy is rising to alarming heights also in southern Sweden. Acta Derm Venereol 2015;95:31-34.
5. Johnston GA. Contributing Members of the British Society for Cutaneous Allergy (BSCA). The rise in prevalence of contact allergy to methylisothiazolinone in the British Isles. Contact Dermatitis 2014;70:238-240.
6. Lammintausta K, Aalto-Korte K, Ackerman L, Alanko K, Berry P, Hasan T, et al. An epidemic of contact allergy to methylisothiazolinone in Finland. Contact Dermatitis 2014;70:184-185.
7. Schwensen JF, Uter W, Bruze M, Svedman C, Goossens A, Wilkinson M, et al. The methylisothiazolinone epidemic: a pan-European prospective study. Contact Dermatitis 2016;75(Suppl.1):68-69.
8. Aerts O, Baeck M, Constandt L, Dezfoulian B, Jacobs MC, Kerre S, et al. The dramatic increase in the rate of methylisothiazolinone contact allergy in Belgium: a multicentre study. Contact Dermatitis 2014;71:41-48.
9. Horst N, Lambert J, Aerts O. Aërogeen contacteczeem door methylisothiazolinone. Ned Tijdschr Dermatol Venereol 2013;23:329-331.


Auteur(s):
dr. Jan R. Mekkes. Dermatoloog, Amsterdam UMC.

27-04-2018 (JRM) - www.huidziekten.nl W3C-html-4.01-valid