Methylisothiazolinone
(C4H5NOS) is an heterocyclic organic compound. The IUPAC-name (International Union of Pure and
Applied Chemistry) is 2-methyl-1,2-thiazol-3-on; synonym:
2-methyl-4-isothiazolin-3-on. Methylisothiazolinon is a very effectief
conservative, in low dose active against grampositive and gramnegative bacteria. Methylisothiazolinon
is used in many cosmetic products, both stay-on- and
rinse-off-products. It is used in moist toilet paper for babies and adults,
and in many consumer- and industrial products. Approximately 5% (2.6-13%) of
tested patients have a positive
patchtest, and in 50-100% the allergic reaction was the cause of the
dermatitis.
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dr. Jan R. Mekkes. Dermatoloog, Amsterdam UMC.