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Formula |
CAS |
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C26H38O5S |
55560-96-8 |
CAS: Chemical Abstract Service Registry Number
Background
Topical corticosteroid used in nasal sprays for the treatment of rhinitis.
Synonyms
(11b)-21-[(2,2-dimethyl-1-oxo-propyl)thi o]-11,17-dihydroxypregn-4-ene-3,20-dione
JO 1016
Pivalone
Procolon
Rectovalone
Tivalon-NT
Tiprederm
Tixocortol-21-pivalate
Tixocortol pivalate
Uses
Nasal sprays
Cross-Reactions
According the A-D grouping, patch-test reactions occur 6-7 times more frequently within well-defined groups of structurally related chemicals than between corticosteroids of different groups (Coopman et al). Tixocortol is used as marker for contact allergy to group A (hydrocortisone) type of steroids.
Unusual Reactions
Airborne contact
References
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1. |
Boujnah-Khouadja, A., et al., Allergy to 2 new corticoid molecules. Contact Dermatitis, 1984. 11(2): p. 83-7. |
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2. |
Camarasa, J.G., et al., Contact allergy to tixocortol pivalate. Contact Dermatitis, 1988. 19(2): p. 147-8. |
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3. |
Hausen, B.M. and J. Foussereau, The sensitizing capacity of tixocortol pivalate. Contact Dermatitis, 1988. 18(1): p. 63-4. |
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4. |
Coopman, S., H. Degreef, and A. Dooms-Goossens, Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. British Journal of Dermatology, 1989. 121(1): p. 27-34. |
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5. |
Dooms-Goossens, A., et al., A survey of the results of patch tests with tixocortol pivalate. Contact Dermatitis, 1989. 20(2): p. 158. |
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6. |
Dooms-Goossens, A.E., et al., Contact allergy to corticosteroids: a frequently missed diagnosis?. Journal of the American Academy of Dermatology, 1989. 21(3 Pt 1): p. 538-43. |
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7. |
Bircher, A.J., Short induction phase of contact allergy to tixocortol pivalate in a nasal spray. Contact Dermatitis, 1990. 22(4): p. 237-8. |
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8. |
Wilkinson, M., P. Cartwright, and J.S. English, The significance of tixocortol-pivalate-positive patch tests in leg ulcer patients. Contact Dermatitis, 1990. 23(2): p. 120-1. |
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9. |
Lauerma, A.I., Screening for corticosteroid contact sensitivity. Comparison of tixocortol pivalate, hydrocortisone-17-butyrate and hydrocortisone. Contact Dermatitis, 1991. 24(2): p. 123-30. |
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10. |
Wilkinson, S.M. and J.S. English, Hydrocortisone sensitivity: a prospective study of the value of tixocortol pivalate and hydrocortisone acetate as patch test markers. Contact Dermatitis, 1991. 25(2): p. 132-3. |
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11. |
Wilkinson, S.M. and J.S. English, Hydrocortisone sensitivity. An investigation into the nature of the allergen. Contact Dermatitis, 1991. 25(3): p. 178-81. |
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12. |
Burden, A.D. and M.H. Beck, Contact hypersensitivity to topical corticosteroids. British Journal of Dermatology, 1992. 127(5): p. 497-500. |
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13. |
Callens, A., et al., Contact stomatitis from tixocortol pivalate. Contact Dermatitis, 1993. 29(3): p. 161. |
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14. |
Lauerma, A.I., et al., Contact hypersensitivity to hydrocortisone-free-alcohol in patients with allergic patch test reactions to tixocortol pivalate. Contact Dermatitis, 1993. 28(1): p. 10-4. |
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15. |
Lepoittevin, J.P., J. Drieghe, and A. Dooms-Goossens, Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids [see comments]. Archives of Dermatology, 1995. 131(1): p. 31-7. |
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16. |
Morton, C. and M. Dohil, A survey of patch test results with tixocortol pivalate in Vancouver. American Journal of Contact Dermatitis, 1995. 6(1): p. 17-18. |
08-01-2012
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