WEKE DELEN TUMOREN home ICD10: n.v.t.

Weke delen tumoren kunnen uitgaan van bindweefsel, vet, spieren, pezen, zenuwen, fascie en zelfs kraakbeen en in alle weefsellagen van huid tot bot voorkomen. Sommige liggen oppervlakkig in de dermis of subcutis en worden door de dermatoloog gediagnosticeerd, dieper gelokaliseerde tumoren worden meestal verwezen naar de algemeen chirurg. Er bestaan zeer veel verschillende weke delen tumoren; Wei et al proberen overzicht te scheppen door ze in te delen naar het overwegende cel type: adipocytic, spindle cell, myxoid, round cell, epitheloid en pleomorf (zie tabel). Daarnaast worden de tumoren geclassificeerd op grond van hun gedrag als benign (goedaardig), intermediate (lokaal agressief of in zeldzame gevallen metastaserend, en malignant (kwaadaardig).


Overzicht van weke delen tumoren:
Adipocytic Lipoma, hibernoma, spindle cell lipoma, atypical lipomatous tumor/well-differentiated liposarcoma, myxoid liposarcoma, dedifferentiated liposarcoma, and pleomorphic liposarcoma
Spindle cell Desmoid tumor (fibromatosis), fibroma, nodular fasciitis, low-grade fibromyxoid sarcoma, dermatofibrosarcoma protuberans, solitary fibrous tumor, fibrosarcoma, leiomyoma, leiomyosarcoma, spindle cell/sclerosing rhabdomyosarcoma, gastrointestinal stromal tumor, schwannoma, neurofibroma, malignant peripheral nerve sheath tumor, synovial sarcoma, spindle cell lipoma, dedifferentiated liposarcoma, and undifferentiated spindle cell sarcoma
Myxoid Myxoma, soft tissue perineurioma, superficial and deep angiomyxoma, myxoid liposarcoma, low-grade fibromyxoid sarcoma, myxofibrosarcoma, myoepithelioma/myoepithelial carcinoma/mixed tumor, extraskeletal myxoid chondrosarcoma, and chordoma
Round cell Ewing sarcoma, embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma, myxoid/round cell liposarcoma, extraskeletal myxoid chondrosarcoma, desmoplastic small round cell tumor, and undifferentiated round cell sarcoma
Epithelioid Sclerosing epithelioid fibrosarcoma, glomus tumor, granular cell tumor, PEComa, rhabdomyoma, myoepithelioma/myoepithelial carcinoma/mixed tumor, epithelioid hemangioendothelioma, epithelioid angiosarcoma, epithelioid leiomyosarcoma, epithelioid sarcoma, clear cell sarcoma, and alveolar soft part sarcoma
Pleomorphic  Pleomorphic liposarcoma, dedifferentiated liposarcoma, pleomorphic rhabdomyosarcoma, myxofibrosarcoma, extraskeletal osteosarcoma, and undifferentiated pleomorphic sarcoma
Wei et al. Arch Pathol Lab Med 2017;141(8):1072-1091.



Referenties
1. Wei S, Henderson-Jackson E, Qian X, Bui MM. Soft Tissue Tumor Immunohistochemistry Update: Illustrative Examples of Diagnostic Pearls to Avoid Pitfalls. Arch Pathol Lab Med 2017;141(8):1072-1091. PDF


Auteur(s):
dr. Jan R. Mekkes. Dermatoloog, Amsterdam UMC.

12-02-2023 (JRM) - www.huidziekten.nl W3C-html-4.01-valid